Reaction Discovery Using Microfluidic-Based Multidimensional Screening of Polycyclic Iminium Ethers
نویسندگان
چکیده
منابع مشابه
Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds.
An automated, silicon-based microreactor system has been developed for rapid, low-volume, multidimensional reaction screening. Use of the microfluidic platform to identify transformations of densely functionalized bicyclo[3.2.1]octanoid scaffolds will be described.
متن کاملDrug Discovery Acceleration Using Digital Microfluidic Biochip Architecture and Computer-aided-design Flow
A Digital Microfluidic Biochip (DMFB) offers a promising platform for medical diagnostics, DNA sequencing, Polymerase Chain Reaction (PCR), and drug discovery and development. Conventional Drug discovery procedures require timely and costly manned experiments with a high degree of human errors with no guarantee of success. On the other hand, DMFB can be a great solution for miniaturization, int...
متن کاملThe discovery of crown ethers.
The discovery of the crown ethers stemmed from efforts to control the catalytic activity of vanadium and copper by complexation with multidentate ligands. The first crown ether, 2,3,11,12-dibenzo-1,4,7,10,13,16-hexaoxacyclo-octadeca-2,11-diene, was obtained in 0.4% yield during an attempt to prepare a phenolic ligand from catechol and bis(2-chloroethyl)ether. This compound, which complexed with...
متن کاملMultidimensional modular microfluidic system.
An extension of our previous work on a genuinely plug-n-play modular microfluidic system is presented for designing and building customized multidimensional (planar, three-dimensional (3D) and their combinations) microfluidic systems as well as for better system integration by allowing direct plug-in of active components such as micropumps.
متن کاملGene Selection using Multidimensional False Discovery Rate
This paper proposes our algorithm for gene selection in microarray data analysis comparing conditions with replicates. Based on background noise computation in replicate array, this algorithm uses the global False Discovery Rate based on ‘Between’ group and ‘Within’ group comparisons of replicates to select the set of differential expressed genes. This method uses two types of statistics that l...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2010
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo100087h